2. •A lipophilic drug that is distributed in a fatty suppository base in low concentration has less tendency to escape to Suppositive definition, of the nature of or involving supposition; suppositional. Base, in chemistry, any substance that in water solution is slippery to the touch, tastes bitter, changes the color of indicators (e.g., turns red litmus paper blue), reacts with acids to form salts, and promotes certain chemical reactions (base catalysis). Hydrophilic suppository bases also melt at body temperature, and … Drug weight=3 gm. Such a hole is undesirable. As the warmth of your body melts the … A lipophilic drug that is distributed in a fatty suppository base in low concentration has less of a tendency to escape to the surrounding aqueous fluids than a hydrophilic drug in its saturation concentrations. The base of the suppository is a combination of coconut oil and cocoa butter, to which is added the desired combination of medicated oils, powdered herbs, and tinctures. Suppository bases usually employed are cocoa butter, glycerinated gelatin, hydrogenated vegetable oils, mixtures of PEGs of various molecular weights, and fatty acid esters of PEG (15). Hard fat suppository bases melt at approximately body temperature. A suppository, which is a general term for a solid dose of medicine that is inserted into the anus or the vagina, can contain different medications, from contraceptives to medication to kill off yeast infections. What is the main advantage of a polyethylene glycol Suppository Base over Oleaginous Bases? Also called. Europe’s fatty bases for suppositories market is expected to grow at a healthy CAGR of 3.2% by generating a revenue of $1,981.3 million, during the projected period. ( sŭ-poz'i-tō'rē ), A small solid preparation shaped for ready introduction into one of the orifices of the body other than the oral cavity (for example, rectum, urethra, vagina), made of a substance, usually medicated, which is solid at room temperatures but melts at body temperature. Wecobee Witepsol. Name some Water-Soluble and Water-Miscible Suppository Bases. A. Oleaginous bases: Theobroma oil or cocoa butter was introduced as base in 1852 and has been one of the most widely used bases. The first is the fat- or oil-type base, which must melt at body temperature to release its medication. Vaginal suppositories are one method of administering a drug to treat a specific disease or condition, or for contraceptive purposes. Now the practical weight of the six suppositories is 14 gm and the total amount of the drug in all suppositories is equal to 6 * 500=3000 mg=3 g. Practical weight=14 gm. 1. suppository - a small plug of medication designed for insertion into the rectum or vagina where it melts. Suppository definition, a solid, conical mass of medicinal substance that melts upon insertion into the rectum or vagina. Suppository bases can be broadly divided into following categories- A. Oleaginous bases. an easily fusible medicated mass for introduction into the rectum, urethra, or vagina. The shape, volume and consistency of suppositories are suitable for rectal application. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. These products are so formulated that after insertion, they will either melt or dissolve in … Definition of suppository : a solid but readily meltable cone or cylinder of usually medicated material for insertion into a bodily passage or cavity (such as the rectum) Examples of suppository in a Sentence Specifications for Suppository Bases 1 Origin & Chemical Composition:  A brief description of the composition of the base reveals the sours of the origin (natural or synthetic or modified natural products). Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. See more. See more. A medicinal substance that slowly dissolves after being inserted into the rectum (or other body cavity). Learn more. Definition Suppositories are solid single-dose preparations intended for rectal application. B. Aqueous bases. Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, Suppress, Obscure, Secure, Reduce, and Assault, Suppress, Obscure, Secure, Reduce, Remove. They come in different shapes and sizes, but they are usually narrowed at … a solid mass of medicinal substance that melts upon insertion into the rectum or vagina. Water-soluble bases dissolve in rectal fluids and suppositories [L. suppositorium , something placed underneath] A semisolid substance for introduction into the rectum, vagina, or urethra, where it dissolves. SUPPOSITORY It is solid dosage form meant to be inserted into Body cavity like rectum, urethra, vagina, where they melt or soften to release the drugs and produce their local or systemic effect. It is comes under semi solid preparation because it is prepared by melting all ingredients (bases and other additives along with active ingredient). All types of suppositories are melt at normal body … This is then poured into the mold, refrigerated to harden, cut into pieces the size of the patient's pinky finger, and inserted as needed. weight is dependent upon the density of the drug, but mainly the density of the base - adult rectal suppositories are shaped as torpedo, bullet, or finger with a rectal dose weight about 2 grams when cocoa butter is used as a base - children rectal suppositories are more pencil shaped and about half the weight of the adult dose (1 gram) suppository meaning: a small, solid pill containing a drug that is put inside the anus, where it dissolves easily. 6. So, the weight of the suppository base is 14 – 3=11 gm. Suppository uses include asthma, allergies, and pain. https://www.thefreedictionary.com/Suppository+bases, A small plug of medication designed to melt at body temperature within a body cavity other than the mouth, especially the rectum or vagina. A suppository is a medication that is inserted into the rectum, vagina, or urethra to be broken down and absorbed by the body. C. Emulsifying bases. SUPPOSITORY BASE Lipid–Water Solubility •The lipid–water partition coefficient of a drug is an important consideration in the selection of the suppository base and in anticipating drug release from that base.  Physical or chemical in- compatibilities with other constituents may be predicted if the exact formula composition is known including preservatives, antioxidants and emulsifiers It may be used to stimulate a bowel movement, but often serves as a vehicle for medicines to be absorbed. Some mixtures and bases have very pronounced contractions (e.g., cocoa butter, PEG) while others have much smaller ones (e.g., glycerinated gelatin, MBK®). Glycerinated Gelatin Polyethylene Glycols. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. suppositories: (sŭ-pŏz′ĭ-tō-rē) plural. https://medical-dictionary.thefreedictionary.com/Suppository+bases. The selection of a suppository base is dependent upon a number of physicochemical variables, including the solubility characteristics of the drug. Suppository bases usually used are theobroma oil, glycerinated gelatin, hydrogenated vegetable oils, mixtures of polyethylene glycols of various molecular weights, and fatty acid esters of polyethylene glycol. So, by the addition of the drug , 1 gm of the suppository base is displaced. Rectal suppositories are suitable for use with a wide range of medicaments including alkaloids boric! 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